| Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2 |
Linlin Hou,Yuanjie Wei,Yingying Lin,Xiwei Wang,Yiwei Lai,Menghui Yin,Yanpu Chen,Xiangpeng Guo,Senbin Wu,Yindi Zhu,Jie Yuan,Muqddas Tariq,Na Li,Hao Sun,Huating Wang,Xiaofei Zhang,Jiekai Chen,Xichen Bao,Ralf Jauch |
2020 Apr; |
Nucleic Acids Research |
| Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway |
Jinlong Chen,Lining Liang,Yuan Li,Yixin Zhang,Mengdan Zhang,Tingting Yang,Fei Meng,Xiaowei Lai,Changpeng Li,Jingcai He,Meiai He,Qiaoran Xu,Qian Li,Ping‐Yee Law,Horace H. Loh,Duanqing Pei,Hao Sun,Hui Zheng |
2020 Apr; |
FASEB Journal |
| Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway |
Lining Liang,Jinlong Chen,Yuan Li,Xiaowei Lai,Hao Sun,Changpeng Li,Mengdan Zhang,Tingting Yang,Fei Meng,Ping-Yee Law,Horace H. Loh,Hui Zheng |
2020 Mar; |
Cell Reports |
| Topology-dependent, bifurcated mitochondrial quality control under starvation |
Yanshuang Zhou,Qi Long,Hao Wu,Wei Li,Juntao Qi,Yi Wu,Ge Xiang,Haite Tang,Liang Yang,Keshi Chen,Linpeng Li,Feixiang Bao,Heying Li,Yaofeng Wang,Min Li,Xingguo Liu |
2020 Mar; |
Autophagy |
| JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells |
Yongli Shan,Yanqi Zhang,Yuan Zhao,Tianyu Wang,Jingyuan Zhang,Jiao Yao,Ning Ma,Zechuan Liang,Wenhao Huang,Ke Huang,Tian Zhang,Zhenghui Su,Qianyu Chen,Yanling Zhu,Chuman Wu,Tiancheng Zhou,Wei Sun,Yanxing Wei,Cong Zhang,Chenxu Li,Shuquan Su,Baojian Liao,Mei Zhong,Xiaofen Zhong,Jinfu Nie,Duanqing Pei,Guangjin Pan |
2020 Jan; |
Nature Communications |
| SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States |
Kaixin Wu,He Liu,Yaofeng Wang,Jiangping He,Shuyang Xu,Yaping Chen,Junqi Kuang,Jiadong Liu,Lin Guo,Dongwei Li,Ruona Shi,Li Shen,Yangming Wang,Xiaofei Zhang,Jie Wang,Duanqing Pei,Jiekai Chen |
2020 Jan; |
Cell Reports |
| Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming |
Keshi Chen,Qi Long,Guangsuo Xing,Tianyu Wang,YiWu,Linpeng Li,Juntao Qi,Yanshuang Zhou,Bochao Ma,Hans R Sch？ler,Jinfu Nie,Duanqing Pei,Xingguo Liu |
2020 Jan; |
EMBO Journal |
| Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors |
Rongqun Guo,Fangxiao Hu,Qitong Weng,Cui Lv,Hongling Wu,Lijuan Liu,Zongcheng Li,Yang Zeng,Zhijie Bai,Mengyun Zhang,Yuting Liu,Xiaofei Liu,Chengxiang Xia,Tongjie Wang,Peiqing Zhou,Kaitao Wang,Yong Dong, Yuxuan Luo,Xiangzhong Zhang,Yuxian Guan,Yang Geng,Juan Du,Yangqiu Li,Yu Lan,Jiekai Chen,Bing Liu,Jinyong Wang |
2020 Jan; |
Cell Research |
| Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist |
Xishan Wu,Yan Zhang,Yong Xu |
2019 Dec; |
Journal of Medicinal Chemistry |
| A Concise Total Synthesis of (+)-Paniculatine |
Jian Liu,Sheng Chen,Ningning Li,Fayang G. Qiu |
2019 Aug; |
Advanced Synthesis & Catalysis |
| One-Pot Enantioselective Synthesis of 2-Pyrrolidinone Derivatives Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter |
Zhuqing Jia,Xiaoyi Hu,Yunlong Zhao,Fayang G. Qiu,Albert S. C. Chan,Junling Zhao |
2019 Dec; |
Organic Letters |
| Rejuvenation of β cells by epigenetic editing |
Wang Tao,Pei Duanqing |
2019 Jan; |
Journal of Clinical Investigation |
| Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
Lin-Ping Wu,Davoud Ahmadvand,Junan Su,Arnaldur Hall,Xiaolong Tan,Z. Shadi Farhangrazi,S. Moein Moghimi |
2019 Oct; |
Nature Communications |
| Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition |
Yi Wu,Keshi Chen,Guangsuo Xing,Linpeng Li,Bochao Ma,Zhijuan Hu,Lifan Duan,Xingguo Liu |
2019 Nov; |
Science Advances |
| SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis |
Pengtao Wang,Jianhong Xia,Leilei Zhang,Shaoyang Zhao,Shengbiao Li,Haiyun Wang,Shan Cheng,Heying Li,Wenguang Yin,Duanqing Pei,Xiaodong Shu |
2019 Oct; |
Cells |
| Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2 |
Vikas Malik,Laura V. Glaser,Dennis Zimmer,Sergiy Velychko,Mingxi Weng,Markus Holzner,Marius Arend,Yanpu Chen,Yogesh Srivastava,Veeramohan Veerapandian,Zahir Shah,Miguel A. Esteban,Huating Wang,Jiekai Chen,Hans R. Sch？ler,Andrew P. Hutchins,Sebastiaan H. Meijsing,Sebastian Pott,Ralf Jauch |
2019 Aug; |
Nature Communications |
| Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway |
Wei Sun,Xuemei Zhao,Zhengqi Wang,Yi Chu,Liufeng Mao,Shaoqiang Lin, Xuefei Gao,Yuna Song,Xiaoyan Hui,Shiqi Jia,Shibing Tang,Yong Xu,Aimin Xu,Kerry Loomes,Cunchuan Wang,Donghai Wu,Tao Nie |
2019 Oct; |
Molecular Metabolism |
| Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition |
Yong Dong,Chengxiang Xia,Qitong Weng,Tongjie Wang,Fangxiao Hu,KaitaoWang,Xiaofei Liu,Yang Geng,Lijuan Liu,Hongling Wu,Juan Du |
2019 Aug; |
Cells |
| Molecular architecture of lineage allocation and tissue organization in early mouse embryo |
Guangdun Peng,Shengbao Suo,Guizhong Cui,Fang Yu,Ran Wang,Jun Chen,Shirui Chen,Zhiwen Liu,Guoyu Chen,Yun Qian,Patrick P. L. tam,Jing-Dong J. Han,Naihe Jing |
2019 Aug; |
Nature |
| Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B |
Longhui Chen,Min Wu,Shengnan Zhang,Wenjuan Tan,Min Guan,Liqiang Feng,Chen Chen,Jun Tao,Ling Chen,Linbing Qu |
2019 Jul; |
FASEB Journal |
| Detection of Novel Mutations Associated with Independent and Cross-resistance to Isoniazid and Protionamide in Mycobacterium tuberculosis Clinical Isolates |
M.M.Islam,Y.Tan,Y.Gao,H.M.A.Hameed,G.Surineni,X.Li,Z.Liu,S.Tan,……,W.W.Yew,J.Liu,N.Zhong,T.Zhang |
2019 Aug; |
Clinical Microbiology and Infection |
| Mesenchymal-epithelial transition in development and reprogramming |
Duanqing Pei,Xiaodong Shu,Ama Gassama-Diagne,Jean Paul Thiery |
2019 Jan; |
Nature Cell Biology |
| Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4 |
Bo Wang,Linlin Wu,Dongwei Li,Yuting Liu,Jing Guo,Chen Li,Yuxiang Yao,Yaofeng Wang,Guoqing Zhao,Xiaoshan Wang,Meijun Fu,He Liu,Shangtao Cao,Chuman Wu,Shengyong Yu,Chunhua Zhou,Yue Qin,Junqi Kuang,Jin Ming,Shilong Chu,Xuejie Yang,Ping Zhu,Guangjin Pan,Jiekai Chen,Jing Liu,Duanqing Pei |
2019 Jun; |
Cell Reports |
| Efficient base editing for multiple genes and loci in pigs using base editors |
Jingke Xie,Weikai Ge,Nan Li,Qishuai Liu,Fangbing Chen,Xiaoyu Yang,Xingyun Huang,Zhen Ouyang,Quanjun Zhang,Yu Zhao,Zhaoming Liu,Shixue Gou,Han Wu,Chengdan Lai,Nana Fan,Qin Jin,Hui Shi,Yanhui Liang,Ting Lan,Longquan Quan,Xiaoping Li,Kepin Wang,Liangxue Lai |
2019 Jun; |
Nature Communications |
| Enantioselective Synthesis of 2‐Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications |
Huaanzi Hu,Fan Teng,Jian Liu,Weiming Hu,Shuang Luo,Qiang Zhu |
2019 Jul; |
Angewandte Chemie-International Edition |
| Selective C-H or N-H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds |
Fan Teng,Weiming Hu,Huaanzi Hu,Shuang Luo,Qiang Zhu |
2019 Mar; |
Advanced Synthesis & Catalysis |
| Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model |
Dickson Adah,Yijun Yang,Quan Liu,Kranthi Gadidasu,Zhu Tao,Songlin Yu,Linglin Dai,Xiaofen Li,Siting Zhao,Limei Qin,Li Qin,Xiaoping Chen |
2019 Apr; |
Cell Communication and Signaling |
| Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer |
Yan Zhang,Xishan Wu,Xiaoqian Xue,Chenchang Li,Junjian Wang,Rui Wang,cheng Zhang,Chao Wang,Yudan Shi,Lingjiao Zou,Qiu Li,Zenghong Huang,Xiaojuan Hao,Kerry M. Loomes,Donghai Wu,Hongwu Chen,Jinxin Xu,Yong Xu |
2019 May; |
Journal of Medicinal Chemistry |
| An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis |
Jiao Li,Kaimeng Huang,Gongcheng Hu,Isaac A. Babarinde,Yaoyi Li,Xiaotao Dong,Yu-Sheng Chen,Liping Shang,Wenjing Guo,Junwei Wang,Zhaoming Chen, Andrew P. Hutchins,Yun-Gui Yang,Hongjie Yao |
2019 Apr; |
Nature Communications |
| Total Synthesis of (-)-Daphenylline |
Bo Xu,Bingyang Wang,Wen Xun,Fayang G.Qiu |
2019 Apr; |
Angewandte Chemie-International Edition |
