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2）Yu, J.^#, Liang, Y.^#, Zhang, Q.^#, Ding, H.^#, Zhang, Q., Xie, M., Zhang, J., Hu, W., Xu, S., Xiao, Y., Xu, S., Na, R.*, Wu, B.*, Zhou, J.*, Chen, H.* (2025) The interplay between human genetics and intratumoral microbiota in the progression of colorectal cancer. Cell Host & Microbe. 2025 May 14; (33) 1-14.

3）Li, X. ^#, Guo W. ^#, Wen, Y. ^#, Meng, C., Zhang, Q., Chen, H., Zhao, X.*, Wu, B.* (2025) Molecular basis for the RNA binding properties of IGF2BP3 tandem RBDs. Structure. 2025 Apr 3;33(4):771-785.e3.

4）Meng, C. ^#, Guo, W. ^#, Xiao, C. ^#, Wen, Y. ^#, Zhu, X., Zhang, Q., Liang, Y., Li, H., Xu, S., Qiu, Y. *, Chen, H. *, Lin, WJ. *, Wu, B.* (2025) Structural Basis for Psilocybin Biosynthesis. Nature Communications. 2025 Mar 22;16(1):2827.

5）Wen, Y.^#, Guo, W.^#, Meng, C., Yang, J., Xu, S., Chen, H.*, Gan, J.*, Wu, B.*. Structural insights into the biosynthetic mechanism of N^α-GlyT and 5-NmdU hypermodifications of DNA. Nucleic Acids Research. 2024 Oct 14;52(18):11083-11097.

6）Guo, W.^#, Wu, W.^#, Wen, Y., Gao, Y., Zhuang, S., Meng, C., Chen, H., Zhao, Z.*, Hu, K.*, Wu, B.*. Structural insights into the catalytic mechanism of the AP endonuclease AtARP. Structure. 2024. 32, 1-15

7）Liu, D.; Dredge, B. K.; Bert, A.; Pillman, K.; Toubia, J.; Guo, W.; Dyakov, B. J.A.; Migault, M.; Conn, V. M.; Conn, S. J.; Gregory, P. A.; Gingras, A-C; Patel, D.; Wu, B.*; Goodall, G.*, ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic acids research. 2024 Feb 9;52(3):1387-1403.

8）Guo, W.^#; Li, X.^#; Fan, J.^#; Li, H.^#; Wen, Y.; Meng, C.; Zhu, X.; Chen, H.; Zhang, Y.; Du, Y.*; Wu, B.*, Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy. iScience. 2023, 26(9):107672

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10）Wen Y.^#, Li X.^#, Guo W, Wu B*. Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins. 2022; 90(6):1233-1241.

11）Liu Y.^#, Zhang L.^#, Guo M., Chen L., Wu B*, Huang H.*. (2021) Structural basis for anti-CRISPR repression mediated by Aca1 and Aca2. Journal of Biological Chemistry. 2021.Dec;297(6):101357.

12）Hou, Y.^#, Sun J.^#, Wu, B.^#, Gao, Y.^#, Nie H., Nie, Z., Quan, S., Wang Y.^*, Cao, X^*, Li, S.^* (2021) CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis. Molecular Plant. 2021 Apr 5;14(4):688-699.

13）Wang, N.^#, Bao, H.^#, Chen, L., Liu, Y., Li, Y.,Wu, B.^*, Huang H.^*Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic acids research. 2019 Nov 4;47(19):10388-10399.

14）Wu, B.^#,*, Zhang, D.^#, Nie, H.^#, Shen, S., Li, Y., Li, S.^* (2019) Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing, RNA Biology, 16:10, 1504-1512

15）Qiu, Q.^#, Mei, H.^#, Deng, X.^#, He, K.^#, Wu, B.^#, Yao, Q., Zhang J., Lu, F., Ma, J.^*, Cao, X.^*(2019) DNA methylation repels targeting of Arabidopsis REF6. Nature Communications. (2019) 10:2063  

16）Wu, B.,^# Su, S.,^# Deepak P. Patil, Liu, H., Gan, J., Samie R. Jaffrey, Ma, J.^* (2018) Molecular Basis for The Specific and Multivariate Recognitions of RNA Substrates by Human hnRNPA2/B1. Nature Communications. 9(1):420.

17）Li, W.^#, Wu, B.^#, Soca, WA., An, L.^* (2018) Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-terminal Domain. Journal of Virology. 92(14). pii: e00324-18.

18）Li, Y.^#, Wu, B.^#, Liu, H., Gao, Y., Yang C., Chen X., Zhang, J., Chen, Y., Gu, Y., Li, J., Ma, J., Gan, J.^* (2018) Structural insights into target DNA recognition by the double homeodomains of human DUX4. Biochemical and Biophysical Research Communications. 2018, 505(4):1161-1167

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参与作者：

1）Yang, M., Ou, T., Wang, L., Zhou, L., Qiu, Z., He, Y., Ren,Y., Huang, L., Wu, B., Orre, L., Lehtiö, J., Dong, W., Wong, PP., Zhu, Y. Phosphorylation of Intrinsically disordered protein FAM246C Drives DDX21 Phase Separation and Remodels Translational Programs to Suppress Tumor Progression in ccRCC. (Under Review)

2）Duan, M.^#, Wen, J. ^#, Cen, Z.^#, Yang, L.^#, Huang, L., Liu, S., Wang, Y., Zhang, Y., Zhou, L., Yuan, L., Jiang, X., Huang, K., Huang, L., Liu, Y., Meng, C., Jian, X., Liu, Y., Lin, J., Zeng, R., Chen, Y., Cen, M., Guo, C., Jia, S., Yan, Y., Chen, A., Lin, L., Zou, X., Huang, X., Wu, H., Liu, C.,  Zhang, W., Liang, Y., Zheng, L., Zhang, X., Chen, Y., Zheng, J., Zhou, T., Zhu, Y., Dai, L., Saw, P., Gu, L., Tian, X., Zhang, Y., Guan, D., Zhu, Y., Zheng, J., Li, Z., Ren, M., Liu, F., Wu, B., Chen, Y., Yan, L., Chen,S.*. Gut microbiota aggravate ischemic stroke via non-host homologous microbial isoenzyme-catalyzed metabolite 2-methylbutyrylcarnitine. (Under Review)

3）Qi, X.^#, Cui, D.^#, Li, X.^#, Fu, W.^#, Ma, H.^#, Guo, W., Wang, J., Song, J., Ma, J., Yang, J., Yu, H., Hong, Yu., Wang, Q., Luo, S., Wang, J., Wu, B., Li, S., Cheng, H., Cheng, M., Li, B., Zhang, K., Li, J.*, Li, F.*. Targeting Nat10 reprograms regulatory T cells function to enhance anti-PD-1 immunotherapy sensitivity in lung cancer. The Journal of Clinical Investigation. 2026

4）Zhang, X.^#, Huang, P.^#, Chen, H.^#, Yang, C.^#, Yang, X., Liu, Y., Wu, B., Zeng, W., Saw, PE., Ye, S., Li, J., Wang, J., Wu, Z., Wang, J., Li, H., Huang, JD., Zeng, M., Li, M., Liu, Q., Su, S., Song, E.*, Chen, J.*. (2025) Chemotherapy-induced CA-repeat DNA fragments in breast cancer trigger robust immune responses. Nature Immunology. 2025 Nov;26(11):1931-1945.

5）Shen, Y.#, Liu, Y.#, Guo, M.#, Mao, S., Chen, R., Wang, M., Li2, Z., Li, Y., Chen, W., Chen, F., Wu, B., Wang, C., Chen, W., Cui, H.*, Yuan, K.*, Huang, H.*. DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate. Nature Structural & Molecular Biology. 2025 Jul;32(7):1193-1204.

6）Mao, Y.^#, Zhang, J.^#, Zhou, Q.^#, He, X.^#, Zheng, Z., Wei, Y., Zhou, K. Lin, Y., Yu, H., Zhang, H., Zhou, Y., Lin, P., Wu, B., Yuan, Y., Zhao, J., Xu, W.*, Zhao, S.*. (2024) Hypoxia Induces Mitochondrial Protein Lactylation to Limit Oxidative Phosphorylation. Cell Research. 2024. Jan;34(1):13-30.

7）Su, S.^#, Li, S.^#, Deng, T.^#, Gao, M., Yin, Y., Peng C., Wu, B., Liu, J., Ma, J.*, Zhang, K.* Structural insights into human m6A-METTL associated complex. Cell Research (2022) 0:1–13.

8）Zhou, Q.^#, Sun, WW. ^#, Chen, JC., Zhang, HL., Liu, J., Lin, Y., Lin PC., Wu, BX., An, YP., Huang L., Sun WX., Zhou, XW., Li, YM., Yuan, YY., Zhao, JY., Xu, W*., Zhao, SM.* Phenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake by Modifying IRβ. Nature Communications. 2022; 13(1):4291.

9）Liu, Y., Chen, L., Wang, N., Wu, B., Bao, H.*, Huang, H.* Structural basis for histone H3 recognition by NASP in Arabidopsis. Journal of Integrative Plant Biology. 2022 Dec;64(12):2309-2313. 

10）Yu, J.^#, He, Z.^#, He, X. Luo, Z., Lian, L., Wu, B., Lan, P.* and Chen, H.* (2021) Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer. Frontiers in Oncology 2021 Nov 5; 11:771099.

11）Yang, Y. ^#, Wang, L.^#, Han, X.^#, Yang, W-L.^#, Zhang, M.^#, Ma, H-L., Sun, B-F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y-S., Xu, J-W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H-L., Huang, Y, Sun, Y-P., Zhao, Y-L., Meng, A., Ma, J.^*, Liu, F.^*, Yang, Y-G.^* (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75, 1188–1202

12）He, J. ^#, Ye, W.^#, Choi, D.^#, Wu, B., Zhai, Y., Guo, B., Duan, S., Wang, Y., Gan, J., Ma, W.*, Ma, J.^* (2019) Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence. Proc. Natl. Acad. Sci. U.S.A. 16;116(16):8054-8059.

13）Yao, Q.^#, Cao, G.^#, Li, M., Wu, B, Zhang, X, Zhang, T., Guo, J., Yin, H, Shi, L., Chen, J, Yu, X., Zheng, L., Ma, J.^*, Su, Y.^*. (2018) Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A. 115(44):11250-11255.

14）Liu, H., Wang, R., Yu, X., Shen, F., Lan, W., Haruehanroengra, P., Yao, Q., Zhang, J., Chen, Y., Li, S., Wu, B., Zheng, L., Ma, J., Lin, J., Cao, C.*, Li, J.*, Sheng, J.*, Gan, J.*. (2018). High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Nucleic acids research. 46(21):11627-11638

15）Liu, H.^#, Yu, X.^#, Chen, Y., Zhang, J., Wu, B., Zheng, L., Haruehanroengra, P., Wang, R., Li, S., Lin, J., Li, J., Sheng, J., Huang, Z. ^*, Ma, J. ^*, Gan, J. ^* (2017) Crystal structure of an RNA-cleaving DNAzyme. Nature Commnications. 8(1):2006 

16）Liu, H., Shen, F., Haruehanroengra, P., Yao, Q., Cheng, Y., Chen, Y., Yang, C., Zhang, J., Wu, B., Luo, Q., Cui, R., Li, J., Ma, J. ^*, Sheng, J. ^*, and Gan, J. ^* (2017) A novel DNA structure containing AgI-mediated G:G and C:C Base Pairs. Angew. Chem. Int. Ed. 56(32):9430-9434.

17）Liu, H., Cai, C., Haruehanroengra, P., Yao, Q., Chen, Y., Yang, C., Luo, Q., Wu, B., Li, J., Ma, J. ^*, Sheng, J. ^*, Gan, J^*. (2017) Flexibility and stabilization of HgII-mediated C: T and T: T base pairs in DNA duplex. Nucleic acids research. 45(5):2910-2918.

18）Zhang, J., Liu, H., Yao, Q., Yu, X., Chen, Y., Cui, R., Wu, B., Zheng, L., Zuo, J., Huang, Z^*., Ma, J^*., Gan, J^*. (2016). Structural basis for single-stranded RNA recognition and cleavage by C3PO. Nucleic acids research. 44(19):9494-9504.

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专利：

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3）吴柏星,孟春艳,郭文婷,温彦；裸盖菇 PsiK 蛋白与 ADP-色胺-Mg2+复合物的三维晶体结构、结晶方法和应用；专利申请号：202411853365.9；

4）吴柏星,孟春艳,郭文婷,温彦；裸盖菇 PsiD 蛋白截短体与色胺复合物的三维晶体结构、结晶方法和应用；专利申请号：202411853417.2；

5）吴柏星,孟春艳,郭文婷,温彦；裸盖菇 PsiM 蛋白、SAH 和 Norbaeocystin 复合物的三维晶体结构及应用；专利申请号：202411853472.1；

6）张玉玲,吴柏星,李鸿炜,温可馨；一种环状RNA的制备方法；专利申请号：202410182401.7；（国际申请号PCT/CN2024/077416）；

7）吴柏星,张玉玲,李鸿炜,温可馨；一种环状多倍串联RNA正义链；专利申请号：202410305556.5（国际申请号PCT/CN2024/077414）；

8）张玉玲,吴柏星,李鸿炜,温可馨；一种环状多倍串联的PCSK9 siRNA；专利申请号：202410182394.0；（国际申请号PCT/CN2024/077415）；